Locally confined epithelial malignancies undergo a phase transition from a solid-like to liquid-like state, a process called unjamming, where associated chronic intracellular strain causes nuclear envelope rupture, leading to the emergence of pro-metastatic traits due to cGAS–STING pathway activation.

中文翻译：

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通过 cGAS–STING 解除肿瘤细胞侵袭

局部局限的上皮恶性肿瘤经历了从固态到液态的相变，这个过程称为解干扰，其中相关的慢性细胞内应变导致核膜破裂，导致由于 cGAS-STING 通路激活而出现促转移特征.