当前位置: X-MOL 学术Eur. J. Org. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Facile Multicomponent Synthesis of Oxazolidinones from Primary Amines and Cesium (Hydrogen)Carbonate
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2023-04-28 , DOI: 10.1002/ejoc.202300135
Lorenz Fehr, Leonard Sewald, Robert Huber, Markus Kaiser

A facile multicomponent, catalyst-free oxazolidinone synthesis from primary aliphatic or aromatic amines and dibromoethane is described. It relies on the usage of cesium carbonate or cesium hydrogencarbonate as the simultaneous base and C1 source, furnishing a broad scope with high yields, including the synthesis of an oxazolidinone-modified dipeptidyl peptidase 8 inhibitor.

中文翻译:

由伯胺和碳酸铯(氢)轻松多组分合成恶唑烷酮

描述了一种由脂肪族或芳香族伯胺和二溴乙烷轻松合成多组分、无催化剂的恶唑烷酮。它依赖于使用碳酸铯或碳酸氢铯作为同时碱和 C1 源,提供了广泛的范围和高产率,包括合成恶唑烷酮修饰的二肽基肽酶 8 抑制剂。
更新日期:2023-04-28
down
wechat
bug