Alternative medicine supplements have become the second most common cause of drug-induced liver injury (DILI) in the US. Kratom is a herbal supplement that is popular for its psychotropic and opioid-like activity. It has become increasingly available in western countries, which often have no specific regulations on its use. However, reports of adverse events linked to kratom use have been increasing; it has been implicated in acute liver injury (mostly cholestatic), acute liver failure, organ dysfunction, toxicity, coma, seizures, and death. Herein, we aim to increase healthcare provider and public awareness of the risks posed by kratom and ultimately support increased regulation of its use.

替代医学补充剂已成为美国药物性肝损伤 (DILI) 的第二大常见原因。卡痛是一种草药补充剂，因其精神作用和类阿片类活性而广受欢迎。它在西方国家越来越普及，但通常没有对其使用的具体规定。然而，与卡痛叶使用相关的不良事件的报告一直在增加；它与急性肝损伤（主要是胆汁淤积）、急性肝衰竭、器官功能障碍、毒性、昏迷、癫痫和死亡有关。在此，我们的目标是提高医疗保健提供者和公众对卡痛叶带来的风险的认识，并最终支持加强对其使用的监管。