Objective

To examine changes in drugs for subacute stroke patients and elucidate the impact of medications on rehabilitation outcomes.

Materials and methods

A total of 295 subacute stroke patients who were admitted to the convalescent rehabilitation ward between June 2018 and May 2019 were included. Polypharmacy was defined as five or more drugs at admission. The primary outcome was the Functional Independence Measure Total score (FIM-T) at discharge. Multiple regression analysis was performed to examine the relationships between the FIM-T at discharge and drug changes or other factors. This study was conducted in two stages. The first analysis included all stroke patients, and the second analysis included only stroke patients with polypharmacy.

Results

On multiple regression analysis, the number of drugs at admission (β=-0.628) was associated with FIM-T at discharge of all stroke patients. Furthermore, the number of additional drugs during hospitalization (β=-1.964) was associated with FIM-T at discharge in the 176 stroke patients with polypharmacy.

Conclusion

This study suggested that the number of drugs at admission and the addition of drugs during hospitalization might have a negative impact on the rehabilitation outcomes of subacute stroke patients.

中文翻译：

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增减药物对亚急性脑卒中患者康复结局的影响

客观的

检查用于亚急性中风患者的药物变化并阐明药物对康复结果的影响。

材料和方法

共纳入 2018 年 6 月至 2019 年 5 月期间入住康复康复病房的 295 名亚急性卒中患者。多重用药被定义为入院时服用五种或更多药物。主要结果是出院时的功能独立性测量总分 (FIM-T)。进行多元回归分析以检查出院时 FIM-T 与药物变化或其他因素之间的关系。这项研究分两个阶段进行。第一项分析包括所有中风患者，第二项分析仅包括接受多种药物治疗的中风患者。

结果

在多元回归分析中，入院时的药物数量 (β=-0.628) 与所有卒中患者出院时的 FIM-T 相关。此外，在 176 名接受多种药物治疗的卒中患者中，住院期间额外药物的数量 (β=-1.964) 与出院时的 FIM-T 相关。

结论

本研究表明，入院时的药物数量和住院期间药物的添加可能对亚急性脑卒中患者的康复结果产生负面影响。