Multicomponent reactions (MCRs) have become popular tools for the efficient generation of sulfonyl-containing molecules. Compared with gaseous SO₂, the solid and stable sulfur dioxide surrogates are more convenient to handle. This significantly promotes the development of multi-component sulfonylation reactions, and some advances have been achieved in the asymmetric MCRs for the construction of high value-added chiral sulfones.

中文翻译：

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基于 SO2 替代物的多组分反应：最新进展

多组分反应（MCR）已成为有效生成含磺酰基分子的流行工具。与气态SO ₂相比，固态且稳定的二氧化硫替代物更易于处理。这极大地促进了多组分磺酰化反应的发展，并且在用于构建高附加值手性砜的不对称MCR方面取得了一些进展。