The creation of nanoparticles with controlled and uniform dimensions and spatially defined functionality is a key challenge. The recently developed living crystallization-driven self-assembly (CDSA) method has emerged as a promising route to one-dimensional (1D) and 2D core–shell micellar assemblies by seeded growth of polymeric and molecular amphiphiles. However, the general limitation of the epitaxial growth process to a single core-forming chemistry is an important obstacle to the creation of complex nanoparticles with segmented cores of spatially varied composition that can be subsequently exploited in selective transformations or responses to external stimuli. Here we report the successful use of a seeded growth approach that operates for a variety of different crystallizable polylactone homopolymer/block copolymer blend combinations to access 2D platelet micelles with compositionally distinct segmented cores. To illustrate the utility of controlling internal core chemistry, we demonstrate spatially selective hydrolytic degradation of the 2D platelets—a result that may be of interest for the design of complex stimuli-responsive particles for programmed-release and cargo-delivery applications.

创建具有受控和统一尺寸以及空间定义功能的纳米粒子是一项关键挑战。最近开发的活性结晶驱动自组装 (CDSA) 方法已成为通过聚合和分子两亲物的种子生长获得一维 (1D) 和二维核壳胶束组装的有前途的途径。然而，外延生长过程对单一核心形成化学的一般限制是创建具有空间变化成分的分段核心的复杂纳米粒子的一个重要障碍，这些纳米粒子随后可以用于选择性转化或对外部刺激的响应。在这里，我们报告成功使用种子生长方法，该方法适用于各种不同的可结晶聚内酯均聚物/嵌段共聚物共混物组合，以获得具有组成不同的分段核的 2D 血小板胶束。为了说明控制内部核心化学的效用，我们展示了 2D 血小板的空间选择性水解降解——这一结果可能对设计用于程序释放和货物输送应用的复杂刺激响应颗粒感兴趣。