COVID-19 相关肺栓塞后慢性血栓栓塞性肺动脉高压和凝块消退,European Respiratory Journal

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COVID-19 相关肺栓塞后慢性血栓栓塞性肺动脉高压和凝块消退
European Respiratory Journal ( IF 24.3 ) Pub Date : 2023-04-20 , DOI: 10.1183/13993003.00171-2023
Cindy M M de Jong ₁ , Chantal Visser ₂ , Remy H H Bemelmans ₃ , Wim G Boersma ₄ , Bram van den Borst ₅ , J Louise I Burggraaf ₆ , Suzanne C Cannegieter _{1,

6} , Arina J Ten Cate-Hoek _{7,

8} , F Nanne Croles ₉ , Harald J Faber ₁₀ , Laura M Faber ₁₁ , Merel E Hellemons _{12,

13} , Lisa M Hessels ₄ , Menno V Huisman ₁ , Pieter W Kamphuisen _{14,

15} , Stephanie C E Koster ₁₆ , Lucia J M Kroft ₁₇ , Ivo van der Lee ₁₈ , Jenneke Leentjens ₁₉ , Karina Meijer ₂₀ , Maarten K Ninaber ₂₁ , Brigitte M Sondermeijer ₁₈ , Susanne Stads ₂₂ , Anton Vonk Noordegraaf ₂₃ , Kristien Winckers _{7,

8} , Marieke J H A Kruip ₂ , Frederikus A Klok ₂₄ ,

Affiliation

Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.
Department of Haematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Internal Medicine, Hospital Gelderse Vallei, Ede, The Netherlands.
Department of Pulmonology, North West Hospital Alkmaar, Alkmaar, The Netherlands.
Department of Pulmonary Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Thrombosis Expertise Center Maastricht and Department of Internal Medicine, Section Vascular Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Cardiovascular Research Institute Maastricht (CARIM), School for Cardiovascular Diseases, Maastricht, The Netherlands.
Department of Internal Medicine, Hospital St. Jansdal, Harderwijk, The Netherlands.
Department of Intensive Care, Wilhelmina Hospital Assen, Assen, The Netherlands.
Department of Internal Medicine, Rode Kruis Hospital, Beverwijk, The Netherlands.
Department of Respiratory Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Erasmus MC Transplant Institute, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Internal Medicine, Tergooi Hospital, Hilversum, The Netherlands.
Department of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Department of Intensive Care, Zaans Medical Centre, Zaandam, The Netherlands.
Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Department of Pulmonology, Spaarne Hospital, Haarlem, The Netherlands.
Department of Internal Medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Haematology, University Medical Centre Groningen, Groningen, The Netherlands.
Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
Department of Intensive Care, Ikazia Hospital, Rotterdam, The Netherlands.
Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands

被诊断为急性肺栓塞 (PE) 的 2019 冠状病毒病 (COVID-19) 幸存者中慢性血栓栓塞性肺动脉高压 (CTEPH) 的发病率目前尚不清楚。考虑到 COVID-19 报告的高 PE 发生率及其潜在独特的病理生理学，可以假设在 COVID-19 相关 PE 后血栓消退的程度较小，并且 CTEPH 的患病率高于非 COVID- 19 相关的 PE 人群。因此，CTEPH 可能是长期 COVID 的可治疗原因，它在急性 COVID-19 期间患有 PE 的患者中捕获了广泛的急性 COVID-19 后遗症 [1]。在这项多中心横断面研究中，我们旨在确定 CTEPH 和复发性静脉血栓栓塞 (VTE) 的患病率，并评估 COVID-19 相关 PE 幸存者的血栓消退情况。

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更新日期：2023-04-20

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