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Targeting multidrug resistant Staphylococcus aureus with cationic chlorpromazine-peptide conjugates
Chemistry - An Asian Journal ( IF 4.1 ) Pub Date : 2023-04-18 , DOI: 10.1002/asia.202300169 Apurva Panjla 1 , Grace Kaul 2, 3 , Abdul Akhir 4 , Deepanshi Saxena 2 , Saurabh Joshi 1 , Chandrima Modak 5 , Dipti Kumari 5 , Alok Jain 5 , Sidharth Chopra 2, 3 , Sandeep Verma 1, 4
Chemistry - An Asian Journal ( IF 4.1 ) Pub Date : 2023-04-18 , DOI: 10.1002/asia.202300169 Apurva Panjla 1 , Grace Kaul 2, 3 , Abdul Akhir 4 , Deepanshi Saxena 2 , Saurabh Joshi 1 , Chandrima Modak 5 , Dipti Kumari 5 , Alok Jain 5 , Sidharth Chopra 2, 3 , Sandeep Verma 1, 4
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Quaternary ammonium peptide conjugates were synthesized to target multidrug resistant pathogens. Compound CPWL showed excellent potential against multidrug resistant S. aureus strains with no cytotoxicity and found to target saFabI as revealed by MD simulation studies.
中文翻译：
用阳离子氯丙嗪肽结合物靶向多重耐药金黄色葡萄球菌
合成季铵肽结合物以靶向多重耐药病原体。化合物CPWL对多重耐药金黄色葡萄球菌菌株显示出极好的潜力，没有细胞毒性，并且发现靶向 saFabI，正如 MD 模拟研究所揭示的那样。
更新日期：2023-04-18
中文翻译：
用阳离子氯丙嗪肽结合物靶向多重耐药金黄色葡萄球菌
合成季铵肽结合物以靶向多重耐药病原体。化合物CPWL对多重耐药金黄色葡萄球菌菌株显示出极好的潜力，没有细胞毒性，并且发现靶向 saFabI，正如 MD 模拟研究所揭示的那样。
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