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Two heads are better than one: Cooperation of two CAPS domains in membrane binding
Structure ( IF 5.7 ) Pub Date : 2023-04-06 , DOI: 10.1016/j.str.2023.03.007
Gang Dong 1
Affiliation  

In this issue of Structure, Zhang et al. report their structural studies on the C2 and PH domains of Ca2+-dependent activator proteins for secretion (CAPS). The two domains form a tightly packed module and generate a continuous basic patch across both domains to substantially enhance CAPS binding to PI(4,5)P2-containing membranes.



中文翻译:

两个头比一个好:两个 CAPS 结构域在膜结合中的合作

在本期结构中,张等人。报告了他们对 Ca 2+依赖性分泌激活蛋白 (CAPS)的 C2 和 PH 结构域的结构研究。这两个域形成一个紧密堆积的模块,并在两个域之间生成连续的基本补丁,以显着增强 CAPS 与含 PI(4,5)P 2的膜的结合。

更新日期:2023-04-09
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