In swine production, stress is a common encounter that leads to serious bacterial infection and adverse effects on growth performance. Though antibiotics have been frequently used to control pathogen spread, sustained negative impacts from antibiotics have been found to affect intestinal integrity and the immune system. Multiple nutritional strategies have shown potential to counteract stress and replace antibiotics, including functional amino acids, low protein diet, plant extracts, organic acids, prebiotics, probiotics, minerals and vitamins. These additives relieve the stress response in swine via different mechanisms and signal transduction pathways. Based on the overview of signaling pathways and stress models, this review highlights the potential of nutritional strategies in swine for preventing or treating stress-related health problems. For wider application in the pig industry, the dose ranges measured require for further validation in different physiological contexts and formulations. In the future, microfluid devices and novel stress models are expected to enhance the efficiency of screening for new anti-stress candidates.

在养猪生产中，压力是一种常见的情况，会导致严重的细菌感染并对生长性能产生不利影响。尽管抗生素经常用于控制病原体传播，但已发现抗生素的持续负面影响会影响肠道完整性和免疫系统。多种营养策略已显示出抵消压力和替代抗生素的潜力，包括功能性氨基酸、低蛋白饮食、植物提取物、有机酸、益生元、益生菌、矿物质和维生素。这些添加剂通过不同的机制和信号转导途径减轻猪的应激反应。基于信号通路和应激模型的概述，这篇综述强调了猪的营养策略在预防或治疗应激相关健康问题方面的潜力。为了在养猪业中得到更广泛的应用，测量的剂量范围需要在不同的生理环境和配方中进行进一步验证。未来，微流体设备和新型压力模型有望提高筛选新抗压力候选人的效率。