A study uses single-cell RNA sequencing to profile human papillomavirus (HPV)-positive and -negative oropharyngeal squamous cell carcinoma, revealing considerable diversity within and between tumors. Within HPV-positive tumors, subsets of malignant cells are found with undetectable HPV expression and decreased HPV-related phenotypes, which may influence prognosis and response to therapy.

中文翻译：

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口咽鳞状细胞肿瘤的意外异质性

一项研究使用单细胞 RNA 测序来分析人乳头瘤病毒 (HPV) 阳性和阴性口咽鳞状细胞癌，揭示了肿瘤内部和肿瘤之间的相当大的多样性。在 HPV 阳性肿瘤中，发现具有检测不到 HPV 表达和 HPV 相关表型减少的恶性细胞亚群，这可能影响预后和对治疗的反应。