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Rapid Decline in Beta-Cell Function and Increasing Adiposity is Associated with Conversion to Type 2 Diabetes in at Risk Latino Youth
Diabetes ( IF 7.7 ) Pub Date : 2023-03-27 , DOI: 10.2337/db22-1034
Alaina P. Vidmar, Ramon Durazo-Arvizu, Marc J. Weigensberg, Tanya L. Alderete, Michael I. Goran

Youth onset type 2 diabetes (T2D) is becoming increasingly prevalent especially among Latinos, and there is limited information on its pathophysiology and causative factors. Here we describe findings from a longitudinal cohort study in 262 Latino children with overweight/obesity at risk of developing T2D with annual measures of oral and intravenous glucose tolerance (IVGTT), body composition and fat distribution. Logistic binomial regression was used to identify significant predictors in those who developed T2D compared to matched controls, and mixed-effects growth models to compare rates of change in metabolic versus adiposity measures between groups. Overall conversion rate to T2D at year five was 2% (n=6). Rate of decline in disposition index (DI), measured with an IVGTT, over 5 years was 3X higher in cases (−341.7 units/year) compared to the extended cohort (−106.7 units/year) and 20X higher compared to controls (−15.2 units/year). Cases had a significantly higher annual increase in fasting glucose, hemoglobin A1c, waist circumference, and trunk fat and there was an inverse correlation between rate of decline in DI and rate of increase in adiposity measures. T2D development in at risk Latino youth is associated with a substantial and rapid decrease in DI that is directly correlated with increase in fasting glucose, HbA1c, and adiposity.

中文翻译:

β 细胞功能的快速下降和肥胖的增加与风险拉丁裔青年转变为 2 型糖尿病有关

青年发病的 2 型糖尿病 (T2D) 越来越普遍,尤其是在拉丁美洲人中,关于其病理生理学和致病因素的信息有限。在这里,我们描述了一项纵向队列研究的结果,该研究对 262 名超重/肥胖且有患 T2D 风险的拉丁裔儿童进行了年度口服和静脉葡萄糖耐量 (IVGTT)、身体成分和脂肪分布测量。Logistic 二项式回归用于确定与匹配对照相比发生 T2D 的那些人的显着预测因子,并使用混合效应生长模型来比较组间代谢与肥胖测量的变化率。第 5 年 T2D 的总体转化率为 2% (n=6)。用 IVGTT 衡量的处置指数 (DI) 在 5 年内的下降率在病例中高出 3 倍 (-341. 7 个单位/年)与扩展队列(-106.7 个单位/年)相比,比对照组高 20 倍(-15.2 个单位/年)。病例的空腹血糖、血红蛋白 A1c、腰围和躯干脂肪的年增长率显着更高,并且 DI 下降率与肥胖指标增加率之间呈负相关。有风险的拉丁裔青年发生 T2D 与 DI 的大幅和快速下降有关,而 DI 与空腹血糖、HbA1c 和肥胖的增加直接相关。
更新日期:2023-03-27
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