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Construction of Axially Chiral Arylpyrroles via Atroposelective Diyne Cyclization
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2023-03-30 , DOI: 10.1002/anie.202303670
Yang-Bo Chen 1 , Li-Gao Liu 1 , Can-Ming Chen 1 , Yi-Xi Liu 1 , Bo Zhou 1 , Xin Lu 1 , Zhou Xu 2 , Long-Wu Ye 1, 3, 4
Affiliation  

A novel copper-catalyzed atroposelective diyne cyclization enables the efficient synthesis of a range of axially chiral arylpyrrole biaryls in good to excellent yields with generally excellent enantioselectivities via oxidation and X−H insertion of vinyl cations. This method gives the first synthesis of mono-substituted 3-arylpyrrole atropisomers and the first atroposelective diyne cyclization.

中文翻译:

通过阻转选择性二炔环化构建轴向手性芳基吡咯

一种新型铜催化的阻转选择性二炔环化能够以良好至优异的收率有效合成一系列轴向手性芳基吡咯联芳基化合物,通过氧化和乙烯基阳离子的 X-H 插入通常具有优异的对映选择性。该方法首次合成了单取代的3-芳基吡咯阻转异构体和第一次阻转选择性二炔环化反应。
更新日期:2023-03-30
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