Filamentous bulking, which results from the overgrowth of filamentous microorganisms, is a common issue that frequently disrupts the stable operation of activated sludge processes. Recent literature has paid attention to the relationship between quorum sensing (QS) and filamentous bulking highlighting that the morphological transformations of filamentous microbes are regulated by functional signal molecules in the bulking sludge system. In response to this, a novel quorum quenching (QQ) technology has been developed to control sludge bulking effectively and precisely by disturbing QS-mediated filamentation behaviors. This paper presents a critical review on the limitations of classical bulking hypotheses and traditional control methods, and provides an overview of recent QS/QQ studies that aim to elucidate and control filamentous bulking, including the characterization of molecule structures, the elaboration of QS pathways, and the precise design of QQ molecules to mitigate filamentous bulking. Finally, suggestions for further research and development of QQ strategies for precise bulking control are put forward.

由丝状微生物过度生长引起的丝状膨胀是一个常见问题，经常扰乱活性污泥工艺的稳定运行。最近的文献关注了群体感应 (QS) 与丝状膨胀之间的关系，强调丝状微生物的形态转变受膨胀污泥系统中功能信号分子的调节。为此，开发了一种新型群体淬灭 (QQ) 技术，通过干扰 QS 介导的丝状化行为来有效、精确地控制污泥膨胀。本文对经典膨胀假设和传统控制方法的局限性进行了批判性回顾，并概述了最近旨在阐明和控制丝状膨胀的 QS/QQ 研究，包括分子结构的表征、QS 通路的阐述以及 QQ 分子的精确设计以减轻丝状膨胀。最后，提出了进一步研究和开发QQ精准群发控制策略的建议。