The development of novel antibacterial materials and a therapeutic strategy to combat multidrug-resistant bacteria is currently a very active research area. The photoactivation of nano-antibacterial agents has attracted considerable interest because of their multimodal antibacterial effect and no drug resistance. In this study, a novel visible light-activated antibacterial composite (BODIPY-ZIF-90) is synthetized by grafting a boron dipyrromethene (BODIPY) photosensitizer on ZIF-90 via a simple aldehyde and amine condensation reaction. BODIPY-ZIF-90 has a uniform rhombic dodecahedron structure with a diameter of 110 nm and micropore volume of 0.03 cm³ g⁻¹. Compared with the individual ZIF-90 and BODIPY photosensitizer, BODIPY-ZIF-90 exhibits strong synergistic visible light-induced (LED 7W) antibiotic property and the MIC is about 5 μg mL⁻¹ to E. coli and S. aureus. BODIPY photosensitizer broaden light absorption region of the composite, and simultaneously the high porosity of ZIF-90 inhibits BODIPY aggregation. The synergetic effect between the BODIPY photosensitizer and ZIF-90 improves ROS generation and accelerates the Zn ions release, which are favorable for light-activated antibacterial activity of BODIPY-ZIF-90. Our work not only provides a feasible strategy to build a light-responsive antibacterial nanoplatform, but also introduces a simple fabrication method for stimuli-responsive porous materials.

中文翻译：

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BODIPY 功能性 ZIF-90 的设计以增强可见光驱动的抗菌性能

开发新型抗菌材料和对抗多重耐药细菌的治疗策略是目前非常活跃的研究领域。纳米抗菌剂的光活化因其具有多模态抗菌作用且无耐药性而受到广泛关注。在这项研究中，通过简单的醛和胺缩合反应，在 ZIF-90 上接枝硼二吡咯亚甲基 (BODIPY) 光敏剂，合成了一种新型可见光激活抗菌复合材料 (BODIPY-ZIF-90)。BODIPY-ZIF-90具有均匀的菱形十二面体结构，直径为110 nm，微孔体积为0.03 cm ³ g ^-1. 与单独的 ZIF-90 和 BODIPY 光敏剂相比，BODIPY-ZIF-90 表现出强协同可见光诱导 (LED 7W) 抗生素特性，对大肠杆菌和金黄色葡萄球菌的 MIC 约为 5 μg mL ^-1。BODIPY 光敏剂拓宽了复合材料的光吸收区域，同时 ZIF-90 的高孔隙率抑制了 BODIPY 的聚集。BODIPY 光敏剂与 ZIF-90 之间的协同作用提高了 ROS 的产生并加速了 Zn 离子的释放，这有利于 BODIPY-ZIF-90 的光激活抗菌活性。我们的工作不仅为构建光响应抗菌纳米平台提供了可行的策略，而且还介绍了一种简单的刺激响应多孔材料的制备方法。