Burnout and depression have overlapping symptoms, but the extent of overlap remains unclear, and the complex relationship between burnout and depression in pharmacists is rarely explored.

We investigated burnout and depression in 1,322 frontline pharmacists, and explored the complex relationship between burnout and depression in those pharmacists using network analysis.

Network analysis showed that there were 5 communities. A partial overlap was found between burnout and depressive symptoms in pharmacists. The nodes MBI-6 (I have become more callous toward work since I took this job), D18 (My life is meaningless), and D10 (I get tired for no reason) had the highest expected influence value. D1 (I feel down-hearted and blue) and D14 (I have no hope for the future) were bridge symptoms connected with emotional exhaustion and reduced professional efficacy, respectively.

A partial overlap exists between burnout and depressive symptoms in pharmacists, mainly in the connection between the emotional exhaustion and reduced professional efficacy and the depressive symptoms. Potential core targets identified in this study may inform future prevention and intervention.

职业倦怠和抑郁症有重叠症状，但重叠的程度仍不清楚，药剂师很少探讨职业倦怠和抑郁症之间的复杂关系。

我们调查了 1,322 名一线药剂师的职业倦怠和抑郁，并使用网络分析探索了这些药剂师职业倦怠和抑郁之间的复杂关系。

网络分析显示有5个社区。在药剂师的倦怠和抑郁症状之间发现了部分重叠。节点 MBI-6（自从接受这份工作后，我对工作变得更加麻木）、D18（我的生活毫无意义）和 D10（我无缘无故地累了）的预期影响值最高。D1（我感到沮丧和忧郁）和 D14（我对未来没有希望）分别是与情绪疲惫和职业效能下降相关的桥梁症状。

药剂师的倦怠和抑郁症状之间存在部分重叠，主要是情绪耗竭和职业效能下降与抑郁症状之间的联系。本研究中确定的潜在核心目标可能为未来的预防和干预提供信息。