The molecular and cellular events that occur during the onset of human organogenesis remain mysterious. We used single-cell and spatial transcriptomics to provide a global view of human embryonic cell-type specification, shedding light on developmental processes such as axial patterning, stage transition, and differences between human and mouse embryonic development.

中文翻译：

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人类器官发生过程中的单细胞和空间转录组学

在人类器官发生过程中发生的分子和细胞事件仍然是个谜。我们使用单细胞和空间转录组学来提供人类胚胎细胞类型规范的全局视图，揭示发育过程，例如轴向模式化、阶段转变以及人和小鼠胚胎发育之间的差异。