ABSTRACT

To determine the clinical efficacy of Zuqing Xu ‘Wuduling’ powder for snake injury on the swelling of the affected limb bitten by Agkistrodon halys. Sixty-five patients with Agkistrodon halys bite were assigned to a treatment group (n = 35) or control group (n = 30). The treatment group was additionally given ‘Wuduling’ powder dressing locally based on the therapy to the control group with conventional Western medicine. Clinical efficacy and improvement of traditional Chinese medicine symptoms and signs in the two groups were evaluated. The treatment group showed a notably higher cure rate than the control group. After 3 days of therapy, the swelling and pain of the affected limb in the treatment group were greatly alleviated. Additionally, after 7 days of therapy, the swelling and pain of the affected limb in the treatment group were more greatly alleviated, and those in the control group were also alleviated. The comparison of the two groups during the same period showed more obvious alleviation of swelling and pain in the treatment group than that in the other. Moreover, the treatment group experienced notably shorter disappearing time of swelling and pain than the control group. After treatment, the levels of CRP, TBIL, Cr, ALT, AST, BUN, CK, LDH and CK-MB in both groups declined notably, with notably lower levels of them in the treatment group than those in the other. Zuqing Xu ‘Wuduling’ powder for snake injury can substantially alleviate the swelling and local pain of affected limbs bitten by Agkistrodon halys.

摘要

确定足清虚‘五毒灵’散剂对蛇伤对白花蛇咬伤患肢肿胀的临床疗效。65 名Agkistrodon halys咬伤患者被分配到治疗组 ( n  = 35) 或对照组 ( n = 30）。治疗组在对照组常规西药治疗的基础上加用‘五毒灵’散敷。评价两组患者临床疗效及中医症状、体征改善情况。治疗组的治愈率明显高于对照组。治疗3天后，治疗组患肢肿痛明显减轻。另外，治疗7天后，治疗组患肢肿痛明显减轻，对照组亦有减轻。两组同期比较，治疗组肿痛减轻较另一组明显。而且，治疗组肿痛消失时间明显短于对照组。治疗后，两组CRP、TBIL、Cr、ALT、AST、BUN、CK、LDH、CK-MB水平均有明显下降，且治疗组明显低于其他组。徐祖清‘五毒灵’蛇伤散能明显减轻蛇咬伤患肢的肿胀和局部疼痛蕲蛇。