Since May 1, 2018, every alcoholic drink sold in Scotland has had minimum unit pricing (MUP) of £0·50 per unit. Previous studies have indicated that the introduction of this policy reduced alcohol sales by 3%. We aimed to assess whether this has led to reductions in alcohol-attributable deaths and hospitalisations. Study outcomes, wholly attributable to alcohol consumption, were defined using routinely collected data on deaths and hospitalisations. Controlled interrupted time series regression was used to assess the legislation's impact in Scotland, and any effect modification across demographic and socioeconomic deprivation groups. The pre-intervention time series ran from Jan 1, 2012, to April 30, 2018, and for 32 months after the policy was implemented (until Dec 31, 2020). Data from England, a part of the UK where the intervention was not implemented, were used to form a control group. MUP in Scotland was associated with a significant 13·4% reduction (95% CI –18·4 to –8·3; p=0·0004) in deaths wholly attributable to alcohol consumption. Hospitalisations wholly attributable to alcohol consumption decreased by 4·1% (–8·3 to 0·3; p=0·064). Effects were driven by significant improvements in chronic outcomes, particularly alcoholic liver disease. Furthermore, MUP legislation was associated with a reduction in deaths and hospitalisations wholly attributable to alcohol consumption in the four most socioeconomically deprived deciles in Scotland. The implementation of MUP legislation was associated with significant reductions in deaths, and reductions in hospitalisations, wholly attributable to alcohol consumption. The greatest improvements were in the four most socioeconomically deprived deciles, indicating that the policy is positively tackling deprivation-based inequalities in alcohol-attributable health harm. Scottish Government.

中文翻译：

---

评估酒精最低单位定价对苏格兰死亡和住院治疗的影响：一项受控中断时间序列研究

自 2018 年 5 月 1 日起，在苏格兰销售的每种酒精饮料的最低单价 (MUP) 为每单位 0·50 英镑。此前的研究表明，这一政策的出台使酒类销量减少了3%。我们的目的是评估这是否导致酒精造成的死亡和住院人数减少。研究结果完全归因于饮酒，是使用常规收集的死亡和住院数据来定义的。受控中断时间序列回归用于评估立法对苏格兰的影响，以及对人口和社会经济贫困群体的任何影响修改。干预前时间序列为2012年1月1日至2018年4月30日，以及政策实施后的32个月（至2020年12月31日）。来自英格兰（英国未实施干预措施的地区）的数据被用来组成对照组。苏格兰的 MUP 与完全归因于饮酒的死亡显着降低 13·4%（95% CI –18·4 至 –8·3；p=0·0004）相关。完全归因于饮酒的住院率下降了 4·1%（–8·3 至 0·3；p=0·064）。效果是由慢性结局（尤其是酒精性肝病）的显着改善所驱动的。此外，MUP立法与苏格兰四个社会经济最贫困的十分位群体中完全归因于饮酒的死亡和住院人数的减少有关。MUP 立法的实施与死亡人数和住院人数的显着减少有关，这完全归因于饮酒。改善最大的是四个社会经济最贫困的十分位群体，这表明该政策正在积极解决因酒精造成的健康危害而导致的贫困不平等问题。苏格兰政府。