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Factors and Mechanisms Influencing Conjugation In Vivo in the Gastrointestinal Tract Environment: A Review
International Journal of Molecular Sciences ( IF 5.6 ) Pub Date : 2023-03-21 , DOI: 10.3390/ijms24065919
Wei Liu 1 , Yanhu Huang 1 , Han Zhang 1 , Ziyi Liu 1 , Quanmin Huan 1 , Xia Xiao 1, 2 , Zhiqiang Wang 1, 2, 3
Affiliation  

The emergence and spread of antibiotic resistance genes (ARGs) have imposed a serious threat on global public health. Horizontal gene transfer (HGT) via plasmids is mainly responsible for the spread of ARGs, and conjugation plays an important role in HGT. The conjugation process is very active in vivo and its effect on the spreading of ARGs may be underestimated. In this review, factors affecting conjugation in vivo, especially in the intestinal environment, are summarized. In addition, the potential mechanisms affecting conjugation in vivo are summarized from the perspectives of bacterial colonization and the conjugation process.

中文翻译:

胃肠道环境中影响体内结合的因素和机制:综述

抗生素抗性基因(ARG)的出现和传播对全球公共卫生造成严重威胁。通过质粒进行的水平基因转移(HGT)主要负责ARG的传播,而接合在HGT中起着重要作用。接合过程在体内非常活跃,其对 ARG 扩散的影响可能被低估。在这篇综述中,总结了影响体内缀合的因素,特别是在肠道环境中。此外,从细菌定植和接合过程的角度总结了影响体内接合的潜在机制。
更新日期:2023-03-21
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