The Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigators interested in diseases of the pancreas. This report provides a summary of the proceedings from the workshop. The goals of the workshop were to forge connections and identify gaps in knowledge that could guide future research directions. Presentations were segregated into six major theme areas, including 1) pancreas anatomy and physiology, 2) diabetes in the setting of exocrine disease, 3) metabolic influences on the exocrine pancreas, 4) genetic drivers of pancreatic diseases, 5) tools for integrated pancreatic analysis, and 6) implications of exocrine–endocrine cross talk. For each theme, multiple presentations were followed by panel discussions on specific topics relevant to each area of research; these are summarized here. Significantly, the discussions resulted in the identification of research gaps and opportunities for the field to address. In general, it was concluded that as a pancreas research community, we must more thoughtfully integrate our current knowledge of normal physiology as well as the disease mechanisms that underlie endocrine and exocrine disorders so that there is a better understanding of the interplay between these compartments.

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胰腺疾病外分泌和内分泌室的综合生理学：研讨会论文集

胰腺疾病外分泌和内分泌室的综合生理学研讨会是在美国国立卫生研究院（马里兰州贝塞斯达）举行的为期 1.5 天的科学会议，吸引了对胰腺疾病感兴趣的临床和基础科学研究人员。本报告总结了研讨会的进展情况。研讨会的目标是建立联系并找出可以指导未来研究方向的知识差距。演讲分为六个主要主题领域，包括 1) 胰腺解剖学和生理学、2) 外分泌疾病背景下的糖尿病、3) 对外分泌胰腺的代谢影响、4) 胰腺疾病的遗传驱动因素、5) 整合胰腺的工具分析，以及 6) 外分泌-内分泌相互作用的影响。对于每个主题，进行了多次演讲后，就与每个研究领域相关的特定主题进行了小组讨论；这些都总结在这里。值得注意的是，讨论确定了该领域的研究差距和解决机会。总的来说，得出的结论是，作为胰腺研究界，我们必须更深入地整合我们现有的正常生理学知识以及内分泌和外分泌疾病的疾病机制，以便更好地了解这些区室之间的相互作用。