The Holocene mud wedge that extends from the Yangtze River mouth to the Taiwan Strait along the Zhejiang–Fujian coast, East China Sea, has attracted considerable research attention; however, the pre-Holocene sedimentary evolution of the same area has been less well documented owing to limited data. We conducted an integrated analysis of 7000 km of high-resolution shallow seismic profiles and two ∼60–80-m-long borehole cores from the Zhejiang coast of eastern China to improve our understanding of the formation of the mud wedge in the context of the post-Late Pleistocene sedimentary evolution of the coastal area. Five major seismic units (numbered SU 1 to SU 5 in descending order) and various subunits that have formed since Marine Oxygen Isotope Stage (MIS) 5 were identified in the study area. SU 5 is recognizable only in the southeastern part of the study area and is interpreted to comprise subtidal to inner-shelf deposits (SU 5b) that were formed during MIS 5 and littoral to tidal-flat deposits (SU 5a) that were formed during the overall sea-level fall of MIS 4 and early MIS 3 (∼60–40 ka). These two subunits are divided by an intervening erosional surface that was likely generated by subaerial exposure of the study area during the sea-level lowstand of MIS 4. During the period from late MIS 3 to MIS 2, the study area was gradually exposed subaerially owing to further sea-level fall, with numerous small rivers incising the underlying strata to form a subaerial unconformity surface (T4). During the early postglacial transgression between ∼15.0 and ∼ 14.0 ka, the study area was progressively flooded, and the river channels were transformed into small estuaries (tidal rivers) that then coalesced into a large-scale, wave-dominated estuary during sea-level rise from ∼14.0 to ∼10.0 ka. The sandy fluvial and/or tidal-river deposits above T4 constitute SU 4. The wave-dominated estuary included a central estuarine bay on the landward side and an estuary-mouth complex on the seaward side, corresponding to fine-grained (muddy) deposits (SU 3a) and coarse-grained (sandy) deposits (SU 3b), respectively. The estuarine deposition concluded with the formation of a transgressive ravinement surface by erosional shoreface retreat during the rising sea level in the early MIS 1 from ∼13.5 ka in the southeasternmost part of the study area to ∼10.0 ka in the area closer to the shore. During the following transgressive phase, the study area was under coastal to shelf sedimentary environments during deposition of SU 2a. Tidal sand ridges (SU 2b) in the eastern part of the study area were formed at ∼11.5 ka and have been active since then. The maximum flooding surface was formed at ∼7.6 ka, and a mud wedge (SU 1) in the study area (except in the eastern part) has been developing since that time and is interpreted to have resulted from the deposition of sediments derived predominantly from the Yangtze River under the modern current system established since the maximum flooding in the Middle Holocene. The study provides new insights into the paleoenvironmental and paleogeographic evolution and facies architecture of the Zhejiang coast since MIS 5, which were controlled by preexisting geomorphological conditions and changes in sea level, hydrodynamics, and sediment supply.