当前位置:
X-MOL 学术
›
Neural Regener. Res.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
New insights into the biological roles of immune cells in neural stem cells in post-traumatic injury of the central nervous system.
Neural Regeneration Research ( IF 6.1 ) Pub Date : 2023-09-01 , DOI: 10.4103/1673-5374.367836 Ning He 1 , Xing-Jia Mao 1 , Yue-Min Ding 2 , Tong Zuo 3 , Ying-Ying Chen 4 , Lin-Lin Wang 1
Neural Regeneration Research ( IF 6.1 ) Pub Date : 2023-09-01 , DOI: 10.4103/1673-5374.367836 Ning He 1 , Xing-Jia Mao 1 , Yue-Min Ding 2 , Tong Zuo 3 , Ying-Ying Chen 4 , Lin-Lin Wang 1
Affiliation
Traumatic injuries in the central nervous system, such as traumatic brain injury and spinal cord injury, are associated with tissue inflammation and the infiltration of immune cells, which simultaneously affect the self-renewal and differentiation of neural stem cells. However, the tissue repair process instigated by endogenous neural stem cells is incapable of restoring central nervous system injuries without external intervention. Recently, resident/peripheral immune cells have been demonstrated to exert significant effects on neural stem cells. Thus, the restoration of traumatic injuries in the central nervous system by the immune intervention in neural stem cells represents a potential therapeutic method. In this review, we discuss the roles and possible mechanisms of immune cells on the self-renewal and differentiation of neural stem cells along with the prognosis of central nervous system injuries based on immune intervention. Finally, we discuss remaining research challenges that need to be considered in the future. Further elucidation of these challenges will facilitate the successful application of neural stem cells in central nervous system injuries.
中文翻译:
神经干细胞中免疫细胞在中枢神经系统创伤后损伤中的生物学作用的新见解。
中枢神经系统外伤,如颅脑外伤、脊髓损伤等,与组织炎症和免疫细胞浸润有关,同时影响神经干细胞的自我更新和分化。然而,在没有外部干预的情况下,内源性神经干细胞引发的组织修复过程无法修复中枢神经系统损伤。最近,常驻/外周免疫细胞已被证明对神经干细胞产生显着影响。因此,通过神经干细胞免疫干预修复中枢神经系统外伤是一种潜在的治疗方法。在这篇评论中,我们讨论了免疫细胞对神经干细胞自我更新和分化的作用和可能的机制,以及基于免疫干预的中枢神经系统损伤的预后。最后,我们讨论了未来需要考虑的剩余研究挑战。进一步阐明这些挑战将有助于神经干细胞在中枢神经系统损伤中的成功应用。
更新日期:2023-03-19
中文翻译:
神经干细胞中免疫细胞在中枢神经系统创伤后损伤中的生物学作用的新见解。
中枢神经系统外伤,如颅脑外伤、脊髓损伤等,与组织炎症和免疫细胞浸润有关,同时影响神经干细胞的自我更新和分化。然而,在没有外部干预的情况下,内源性神经干细胞引发的组织修复过程无法修复中枢神经系统损伤。最近,常驻/外周免疫细胞已被证明对神经干细胞产生显着影响。因此,通过神经干细胞免疫干预修复中枢神经系统外伤是一种潜在的治疗方法。在这篇评论中,我们讨论了免疫细胞对神经干细胞自我更新和分化的作用和可能的机制,以及基于免疫干预的中枢神经系统损伤的预后。最后,我们讨论了未来需要考虑的剩余研究挑战。进一步阐明这些挑战将有助于神经干细胞在中枢神经系统损伤中的成功应用。