Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cell carcinoma. Immunoglobulin FcγRIIa receptor (FCGR2A) has been implicated in various cancers, however, its role on ccRCC is not well studied. A total of 151 patients with ccRCC were recruited for the study. Cox proportional hazards regression analysis was performed to calculate the hazard radios of FCGR2A expression and tumor characteristics. Pathological changes associated with ccRCC in tumor tissue sections were analyzed by hematoxylin-eosin staining. Immunohistochemical and immunofluorescence staining were used to detect the protein expression of FCGR2A in the tissue sections. Correlation between the expression of FCGR2A and the overall survival (OS) of ccRCC patients was analyzed by biological process neural network and support vector machine. The expression of FCGR2A was significantly correlated with the TNM of tumor, family history of ccRCC and Fuhrman stage of ccRCC. Patients with high FCGR2A expression in the tumor tissue, had poorer OS than the patients with low and moderate FCGR2A expression. The Receiver operating characteristic curve showed that FCGR2A can be used as a sensitive and specific biomarker for the diagnosis of ccRCC. Western blotting revealed that the FCGR2A was expressed at higher levels in the ccRCC tissues. Biological process neural network and support vector machine fitting showed that the R2 between FCGR2A and survival time of ccRCC patients was 0.8429 and 0.7669, respectively. FCGR2A is highly expressed in ccRCC, higher expression of FCGR2A is associated with poorer OS of ccRCC.

中文翻译：

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FCGR2A 是透明细胞肾细胞癌生存预后不良的一种新的潜在靶点。

透明细胞肾细胞癌（ccRCC）是最常见的肾细胞癌类型。免疫球蛋白 FcγRIIa 受体 (FCGR2A) 与多种癌症有关，但其在 ccRCC 中的作用尚未得到充分研究。该研究总共招募了 151 名 ccRCC 患者。进行Cox比例风险回归分析以计算FCGR2A表达和肿瘤特征的风险放射。通过苏木精-伊红染色分析肿瘤组织切片中与ccRCC相关的病理变化。免疫组化和免疫荧光染色检测组织切片中FCGR2A蛋白的表达。通过生物过程神经网络和支持向量机分析FCGR2A的表达与ccRCC患者总生存期（OS）之间的相关性。FCGR2A的表达与肿瘤TNM、ccRCC家族史、ccRCC Fuhrman分期显着相关。肿瘤组织中 FCGR2A 高表达的患者的 OS 比 FCGR2A 低和中度表达的患者差。受试者工作特征曲线表明 FCGR2A 可作为诊断 ccRCC 的敏感且特异的生物标志物。Western blotting显示FCGR2A在ccRCC组织中表达水平较高。生物过程神经网络和支持向量机拟合显示FCGR2A与ccRCC患者生存时间之间的R2分别为0.8429和0.7669。FCGR2A 在 ccRCC 中高表达，FCGR2A 高表达与 ccRCC 较差的 OS 相关。