Ovarian, endometrial, and cervical cancer are common gynecologic malignancies, and their incidence is increasing year after year, with a younger patient population at risk. An exosome is a tiny “teacup-like” blister that can be secreted by most cells, is highly concentrated and easily enriched in body fluids, and contains a large number of lncRNAs carrying some biological and genetic information that can be stable for a long time and is not affected by ribonuclease catalytic activity. As a cell communication tool, exosome lncRNA has the advantages of high efficiency and high targeting. Changes in serum exosome lncRNA expression in cancer patients can accurately reflect the malignant biological behavior of cancer cells. Exosome lncRNA has been shown in studies to have broad application prospects in cancer diagnosis, monitoring cancer recurrence or progression, cancer treatment, and prognosis. The purpose of this paper is to provide a reference for clinical research on the pathogenesis, diagnosis, and treatment of gynecologic malignant tumors by reviewing the role of exosome lncRNA in gynecologic cancers and related molecular mechanisms.

中文翻译：

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外泌体 lncRNA 的全面概述：妇科癌症的新兴生物标志物和潜在疗法

卵巢癌、子宫内膜癌和宫颈癌是常见的妇科恶性肿瘤，其发病率逐年上升，并且年轻的患者人群处于危险之中。外泌体是一种微小的“茶杯状”泡泡，大多数细胞都能分泌，高度浓缩，容易在体液中富集，含有大量lncRNAs，携带一些生物和遗传信息，可以长期稳定并且不受核糖核酸酶催化活性的影响。外泌体lncRNA作为细胞通讯工具，具有高效、高靶向等优点。癌症患者血清外泌体lncRNA表达量的变化可以准确反映癌细胞的恶性生物学行为。Exosome lncRNA已在研究中显示在癌症诊断中具有广阔的应用前景，监测癌症复发或进展、癌症治疗和预后。本文旨在通过综述外泌体lncRNA在妇科恶性肿瘤中的作用及相关分子机制，为妇科恶性肿瘤的发病机制、诊断和治疗的临床研究提供参考。