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Blood pressure-driven rupture of blood vessels
Journal of the Mechanics and Physics of Solids ( IF 5.3 ) Pub Date : 2023-03-15 , DOI: 10.1016/j.jmps.2023.105274
Wei-Kang Sun, B.B. Yin, Lu-Wen Zhang, K.M. Liew

To develop better diagnosis and treatment techniques of cardiovascular disease such as aneurysm, further understandings of the biomechanical mechanisms and failure behaviors of blood vessels is urgent. Importantly, blood pressure, residual stress, loads from surrounding tissues, and fluid-structure interactions greatly influence the spatiotemporal evolution of deformation and damage of blood vessels. However, directly incorporating these effects into a fluid-structure interaction mechanism analysis of blood vessels remains challenging. Here, we proposed a novel virtual bar model for surrounding tissues and correlated residual stress and loads from the surrounding tissues with perivascular pressures of blood vessels based on a strategy of pressure decomposition. Meanwhile, we developed a pristine meshfree framework incorporating both the Fung-type hyperelasticity and the Casson's non-Newtonian fluid model for modeling the deformation and rupture of blood vessels. An essential physical phenomenon, blood pressure-induced spontaneous ruptures of blood vessels, are successfully captured using our method. It should be highlighted that the effects of material constitutive model, loads from surrounding tissues, the off-axis distance of aneurysm and outlet resistance can be systematically characterized using the proposed model. Another valuable finding is that surrounding tissues have significant effects on the deformation and damage behaviors of blood vessel, however, it was ignored in most of biomechanics simulations. Our work will provide a landmark computational framework for studying surrounding tissues and a potential numerical implementation for fluid-driven failure analysis in biological tissues.



中文翻译:

血压驱动的血管破裂

为了开发更好的动脉瘤等心血管疾病的诊断和治疗技术,迫切需要进一步了解血管的生物力学机制和失效行为。重要的是,血压、残余应力、来自周围组织的载荷以及流体-结构相互作用极大地影响血管变形和损伤的时空演变。然而,将这些影响直接纳入血管的流固耦合机制分析仍然具有挑战性。在这里,我们基于压力分解策略提出了一种新的周围组织虚拟杆模型,并将来自周围组织的残余应力和负荷与血管的血管周围压力相关联。同时,我们开发了一个原始的无网格框架,结合了 Fung 型超弹性和 Casson 的非牛顿流体模型,用于模拟血管的变形和破裂。使用我们的方法成功捕获了一种基本的物理现象,即血压引起的血管自发破裂。应该强调的是,材料本构模型的影响、来自周围组织的载荷、动脉瘤的离轴距离和出口阻力可以使用所提出的模型系统地表征。另一个有价值的发现是周围组织对血管的变形和损伤行为有显着影响,然而,它在大多数生物力学模拟中被忽略了。

更新日期:2023-03-16
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