The β2-receptor mediates the metabolic response to epinephrine. This study investigates the impact of the β2-receptor gene (ADRB2) polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypoglycemia. Twenty-five healthy male subjects selected according to ADRB2 genotype being homozygous for either Gly16 (GG; n=12) or Arg16 (AA; n=13) participated in 4 trial days (D1-4), D1pre and D4post with epinephrine 0.06 ug kg-1 min-1 infusion, and D2hypo1-2 and D3hypo3 with three periods of hypoglycemia by an insulin-glucose clamp. At D1pre the insulin (44 ± 8 vs. 93 ± 13 pmol l-1 h; P = 0.0051) and glycerol (79 ± 12 vs. 115 ± 14 µmol l-1 h; P = 0.041) and free fatty acids (FFA) (724 ± 96 vs. 1113 ± 140 µmol l-1 h; P = 0.033) responses (mean ± SEM of area under the curve) to epinephrine were decreased in AA subjects compared to GG subjects but without difference in glucose response. There were no difference in response to epinephrine between genotype groups after repetitive hypoglycemia at D4post. The metabolic substrate response to epinephrine is decreased in AA subjects compared to GG subjects, but without difference between genotype groups after repetitive hypoglycemia. Article Highlights This study investigates the impact of the β2-receptor gene (ADRB2) polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypoglycemia. Healthy male subjects being homozygous for either Gly16 (GG; n=12) or Arg16 (AA; n=13) participated in the study. Healthy people with the GG genotype have increased metabolic response to epinephrine, compared to the AA genotype, but without difference between genotype groups after repetitive hypoglycemia.

中文翻译：

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β2受体基因多态性对反复低血糖后肾上腺素代谢反应的影响

β2 受体介导对肾上腺素的代谢反应。本研究调查了 β2 受体基因 (ADRB2) 多态性 Gly16Arg 对反复低血糖前后肾上腺素代谢反应的影响。根据 ADRB2 基因型选择的 25 名健康男性受试者是 Gly16（GG；n=12）或 Arg16（AA；n=13）的纯合子，参加了 4 个试验日（D1-4），D1pre 和 D4post 肾上腺素 0.06 ug kg-1 min-1 输注，以及 D2hypo1-2 和 D3hypo3，通过胰岛素-葡萄糖钳夹进行三个低血糖期。在 D1pre，胰岛素（44 ± 8 对比 93 ± 13 pmol l-1 h；P = 0.0051）和甘油（79 ± 12 对比 115 ± 14 µmol l-1 h；P = 0.041）和游离脂肪酸（FFA ) (724 ± 96 对比 1113 ± 140 µmol l-1 h；P = 0。033) 与 GG 受试者相比，AA 受试者对肾上腺素的反应（曲线下面积的平均值± SEM）有所降低，但葡萄糖反应没有差异。在 D4 后反复低血糖后，基因型组之间对肾上腺素的反应没有差异。与 GG 受试者相比，AA 受试者对肾上腺素的代谢底物反应降低，但在重复低血糖后基因型组之间没有差异。文章要点 本研究调查了 β2 受体基因 (ADRB2) 多态性 Gly16Arg 对反复低血糖前后肾上腺素代谢反应的影响。Gly16 (GG；n=12) 或 Arg16 (AA；n=13) 纯合的健康男性受试者参与了该研究。具有 GG 基因型的健康人对肾上腺素的代谢反应增加，