Activation of a crucial immune adaptor protein, STING, is tightly regulated by subcellular trafficking, but how it is deactivated remains less well defined. A study now shows that ESCRT-dependent encapsulation of STING-carrying vesicles by lysosomal compartments — through the process of microautophagy — mediates the termination of STING signalling.

中文翻译：

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STING 通过微自噬进行 ESCR 降解

重要的免疫衔接蛋白 STING 的激活受到亚细胞运输的严格调控，但它如何失活尚不清楚。现在的一项研究表明，溶酶体隔室对携带 STING 的囊泡的 ESCRT 依赖性封装——通过微自噬过程——介导了 STING 信号传导的终止。