For hydrogel wound dressings, it remains a great challenge to simultaneously achieve multifunctional hydrogels with wound-matching mechanical performance, antibacterial activity and monitoring capability for the integration of treatment and rehabilitation training monitoring during wound repair. Inspired by the highly ordered hierarchical structures of natural soft tissues, ordered magnetoelectric nanosheet structures are introduced into gelatin-oxidized dextran (Gel-ODex) hydrogels to endow the hydrogel with anisotropy and versatility in this study. First, magnetoelectric nanosheets (Fe₃O₄-PDA-rGO, MPG) containing polydopamine (PDA) were obtained by dopamine (DA)-mediated formation of Fe₃O₄ nanoparticles in situ on the surface of reduced graphene oxide (rGO). Then, anisotropic Gel-ODex-MPG (GOH-MPG) hydrogels were prepared by introducing MPG into the Gel-ODex hydrogel network under a magnetic field. The GOH-MPG hydrogel exhibited anisotropic mechanical and conductive properties and great photothermal antibacterial performance under near-infrared light (NIR, 808 nm). In addition, the anisotropic GOH-MPG conductive hydrogel could accelerate infected wound healing and sensitively detect human movements, which is helpful for monitoring the wound status and for rehabilitation training during wound recovery. To the best of our knowledge, this was the first exploration of the combination of anisotropic hydrogels in the field of wound therapy and wearable sensors, which sheds light on developing anisotropic hydrogels with multifunctionality in tissue repair and personal health monitoring to realize the integration of treatment and rehabilitation training monitoring.

对于水凝胶伤口敷料，同时实现具有伤口匹配机械性能、抗菌活性和监测能力的多功能水凝胶，用于伤口修复过程中治疗和康复训练监测的一体化，仍然是一个巨大的挑战。受天然软组织高度有序的层次结构的启发，本研究将有序的磁电纳米片结构引入明胶氧化葡聚糖 (Gel-ODex) 水凝胶中，赋予水凝胶各向异性和多功能性。首先，通过多巴胺（DA）介导的Fe ₃ O ₄形成获得含有聚多巴胺（PDA）的磁电纳米片（Fe ₃ O _{4 -PDA-rGO，MPG）}还原氧化石墨烯 (rGO) 表面上的原位纳米粒子。然后，通过在磁场下将 MPG 引入 Gel-ODex 水凝胶网络来制备各向异性 Gel-ODex-MPG (GOH-MPG) 水凝胶。GOH-MPG 水凝胶在近红外光（NIR，808 nm）下表现出各向异性的机械和导电性能以及出色的光热抗菌性能。此外，各向异性GOH-MPG导电水凝胶可以加速感染伤口的愈合，并灵敏地检测人体运动，这有助于伤口状态的监测和伤口恢复过程中的康复训练。据我们所知，这是在伤口治疗领域首次探索各向异性水凝胶与可穿戴传感器的结合，