Although a growing number of studies have attempted to uncover the relationship between plasma lipids and the risk of aortic aneurysm (AA), it remains controversial. Meanwhile, the relationship between plasma lipids and the risk of aortic dissection (AD) has not been reported on. We conducted a two-sample Mendelian randomization (MR) analysis to evaluate the potential relationship between genetically predicted plasma levels of lipids and the risk of AA and AD. Summary data on the relationship between genetic variants and plasma lipids were obtained from the UK Biobank and Global Lipids Genetics Consortium studies, and data on the association between genetic variants and AA or AD were taken from the FinnGen consortium study. Inverse-variance weighted (IVW) and four other MR analysis methods were used to evaluate effect estimates. Results showed that genetically predicted plasma levels of low-density lipoprotein cholesterol, total cholesterol, or triglycerides were positively correlated with the risk of AA, and plasma levels of high-density lipoprotein cholesterol were negatively correlated with the risk of AA. However, no causal relationship was found between elevated lipid levels and the risk of AD. Our study revealed a causal relationship between plasma lipids and the risk of AA, while plasma lipids had no effect on the risk of AD.

中文翻译：

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血浆脂质水平与主动脉瘤和主动脉夹层风险之间的遗传关联：双样本孟德尔随机研究。

尽管越来越多的研究试图揭示血浆脂质与主动脉瘤 (AA) 风险之间的关系，但仍存在争议。同时，血浆脂质与主动脉夹层（AD）风险之间的关系尚未见报道。我们进行了双样本孟德尔随机化 (MR) 分析，以评估遗传预测的血浆脂质水平与 AA 和 AD 风险之间的潜在关系。遗传变异与血脂之间关系的汇总数据来自英国生物银行和全球脂质遗传学联盟的研究，遗传变异与 AA 或 AD 之间关联的数据来自 FinnGen 联盟的研究。逆方差加权 (IVW) 和其他四种 MR 分析方法用于评估效果估计。结果显示，基因预测的血浆低密度脂蛋白胆固醇、总胆固醇或甘油三酯水平与 AA 风险呈正相关，血浆高密度脂蛋白胆固醇水平与 AA 风险呈负相关。然而，没有发现血脂水平升高与 AD 风险之间存在因果关系。我们的研究揭示了血脂与 AA 风险之间的因果关系，而血脂对 AD 风险没有影响。未发现血脂水平升高与 AD 风险之间存在因果关系。我们的研究揭示了血脂与 AA 风险之间的因果关系，而血脂对 AD 风险没有影响。未发现血脂水平升高与 AD 风险之间存在因果关系。我们的研究揭示了血脂与 AA 风险之间的因果关系，而血脂对 AD 风险没有影响。