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Ferroptosis, pyroptosis and necroptosis in acute respiratory distress syndrome
Cell Death Discovery ( IF 7 ) Pub Date : 2023-03-10 , DOI: 10.1038/s41420-023-01369-2
Yongxin Zheng 1 , Yongbo Huang 1 , Yonghao Xu 1 , Ling Sang 1 , Xiaoqing Liu 1 , Yimin Li 1
Affiliation  

Acute respiratory distress syndrome (ARDS) is an acute and uncontrolled pulmonary inflammation caused by various insults. Cell death is a critical mechanism in the pathogenesis of ARDS. Ferroptosis, a novel form of cell death defined as iron-mediated lipid peroxidation, has been shown to play a role in the pathogenesis of ARDS. Additionally, pyroptosis and necroptosis are also involved in the pathophysiological process of ARDS. The crosstalk among ferroptosis, pyroptosis, and necroptosis is getting increasing attention. Therefore, this review will mainly summarize the molecular mechanisms and central pathophysiological role of ferroptosis in ARDS. We will also discuss our understanding of pyroptosis and necroptosis as they pertain to the pathogenesis of ARDS. Furthermore, we also describe the pathological processes that engage crosstalk among ferroptosis, pyroptosis, and necroptosis. We consider that individual pathways of ferroptosis, pyroptosis, and necroptosis are highly interconnected and can compensate for one another to promote cell death.



中文翻译:

急性呼吸窘迫综合征中的铁死亡、焦亡和坏死

急性呼吸窘迫综合征 (ARDS) 是由各种损伤引起的急性且不受控制的肺部炎症。细胞死亡是 ARDS 发病机制中的关键机制。铁死亡是一种新的细胞死亡形式,被定义为铁介导的脂质过氧化,已被证明在 ARDS 的发病机制中发挥作用。此外,焦亡和坏死也参与了ARDS的病理生理过程。ferroptosis、pyroptosis 和 necroptosis 之间的串扰越来越受到关注。因此,本文将主要总结铁死亡在ARDS中的分子机制和中枢病理生理作用。我们还将讨论我们对细胞焦亡和坏死性凋亡的理解,因为它们与 ARDS 的发病机制有关。此外,我们还描述了参与铁死亡、细胞焦亡和坏死性凋亡之间串扰的病理过程。我们认为铁死亡、细胞焦亡和细胞坏死的各个途径高度相互关联,可以相互补偿以促进细胞死亡。

更新日期:2023-03-11
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