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Recent Advances in Cardiovascular Disease Biosensors and Monitoring Technologies
ACS Sensors ( IF 8.9 ) Pub Date : 2023-03-09 , DOI: 10.1021/acssensors.2c02311
Lichao Tang 1, 2 , Jiyuan Yang 1, 3 , Yuxi Wang 1, 4 , Ruijie Deng 4, 5
Affiliation  

Cardiovascular disease (CVD) causes significant mortality and remains the leading cause of death globally. Thus, to reduce mortality, early diagnosis by measurement of cardiac biomarkers and heartbeat signals presents fundamental importance. Traditional CVD examination requires bulky hospital instruments to conduct electrocardiography recording and immunoassay analysis, which are both time-consuming and inconvenient. Recently, development of biosensing technologies for rapid CVD marker screening attracted great attention. Thanks to the advancement in nanotechnology and bioelectronics, novel biosensor platforms are developed to achieve rapid detection, accurate quantification, and continuous monitoring throughout disease progression. A variety of sensing methodologies using chemical, electrochemical, optical, and electromechanical means are explored. This review first discusses the prevalence and common categories of CVD. Then, heartbeat signals and cardiac blood-based biomarkers that are widely employed in clinic, as well as their utilizations for disease prognosis, are summarized. Emerging CVD wearable and implantable biosensors and monitoring bioelectronics, allowing these cardiac markers to be continuously measured are introduced. Finally, comparisons of the pros and cons of these biosensing devices along with perspectives on future CVD biosensor research are presented.

中文翻译:

心血管疾病生物传感器和监测技术的最新进展

心血管疾病 (CVD) 导致大量死亡率,并且仍然是全球死亡的主要原因。因此,为了降低死亡率,通过测量心脏生物标志物和心跳信号进行早期诊断具有重要意义。传统的CVD检查需要笨重的医院仪器进行心电图记录和免疫分析,既费时又不方便。最近,用于快速 CVD 标志物筛选的生物传感技术的发展引起了极大的关注。由于纳米技术和生物电子学的进步,开发了新型生物传感器平台,以实现在整个疾病进展过程中的快速检测、准确量化和连续监测。使用化学、电化学、光学、和机电手段进行了探索。本综述首先讨论了 CVD 的患病率和常见类别。然后,总结了广泛应用于临床的心跳信号和基于心脏血液的生物标志物,以及它们在疾病预后中的应用。介绍了新兴的 CVD 可穿戴和植入式生物传感器和监测生物电子学,可以连续测量这些心脏标记物。最后,比较了这些生物传感设备的优缺点以及对未来 CVD 生物传感器研究的展望。介绍了新兴的 CVD 可穿戴和植入式生物传感器和监测生物电子学,可以连续测量这些心脏标记物。最后,比较了这些生物传感设备的优缺点以及对未来 CVD 生物传感器研究的展望。介绍了新兴的 CVD 可穿戴和植入式生物传感器和监测生物电子学,可以连续测量这些心脏标记物。最后,比较了这些生物传感设备的优缺点以及对未来 CVD 生物传感器研究的展望。
更新日期:2023-03-09
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