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SARS-CoV-2 causes DNA damage, cellular senescence and inflammation
Nature Cell Biology ( IF 21.3 ) Pub Date : 2023-03-09 , DOI: 10.1038/s41556-023-01097-w


We discovered that SARS-CoV-2 infection causes DNA damage both in cultured cells and in vivo. Mechanistically, SARS-CoV-2 degrades the enzyme CHK1, which leads to a reduction in dNTPs and impaired DNA replication. Moreover, inhibition of the formation of binding protein 53BP1 foci by the SARS-CoV-2 nucleocapsid protein hinders the repair of damaged DNA. The ensuing accumulation of DNA damage causes cellular senescence and inflammation.

中文翻译:

SARS-CoV-2 导致 DNA 损伤、细胞衰老和炎症

我们发现 SARS-CoV-2 感染会导致培养细胞和体内的 DNA 损伤。从机制上讲,SARS-CoV-2 会降解 CHK1 酶,从而导致 dNTP 减少和 DNA 复制受损。此外,SARS-CoV-2 核衣壳蛋白对结合蛋白 53BP1 病灶形成的抑制阻碍了受损 DNA 的修复。随后的 DNA 损伤累积导致细胞衰老和炎症。
更新日期:2023-03-09
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