Abstract

Seven new pentasaccharides (1–7), rehmaglupentasaccharides A-G, were isolated from the air-dried roots of Rehmannia glutinosa. Their structures were established from the spectroscopic data obtained and by chemical evidence. The known verbascose (8) and stachyose (9) were also obtained in the current investigation, and the structure of stachyose was unequivocally defined using X-ray diffraction data. Compounds 1–9 were tested for their cytotoxicity against five human tumor cell lines, influence on dopamine receptor activation, and proliferation effects against Lactobacillus reuteri.

中文翻译：

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地黄根部的七种新戊糖

摘要

从Rehmannia glutinosa的风干根中分离出七种新的五糖 ( 1 – 7 )，rehmaglupentasaccharides AG 。它们的结构是根据获得的光谱数据和化学证据确定的。在当前的研究中还获得了已知的毛蕊花糖 ( 8 ) 和水苏糖 ( 9 )，并且使用 X 射线衍射数据明确定义了水苏糖的结构。测试了化合物1 – 9对五种人类肿瘤细胞系的细胞毒性、对多巴胺受体激活的影响以及对罗伊氏乳杆菌的增殖作用。