Tetracycline (TC) residues not only endanger human health, but also are detrimental to the sustainable development of aquaculture and animal husbandry. Herein, a novel fluorescence sensor with high sensitivity and selectivity was developed based on nitrogen-doped carbon dots embedded in zinc-based metal-organic frameworks and incorporating molecularly imprinted polymer (ZIF-8&N-CDs@MIP). The physical and chemical properties of the ZIF-8&N-CDs@MIP had been characterized by SEM, TEM, FTIR, XRD, BET, TGA, etc. Under optimal conditions, the limit of detection (LOD) of the novel sensor was 0.045 μg mL⁻¹ with the concentration of TC in the range of 0.1–4.0 μg mL⁻¹. In addition, the prepared imprinted polymers showed superior adsorption selectivity to tetracycline compared with non-imprinted polymers, and the quenching mechanism of ZIF-8&N-CDs@MIP was demonstrated to be attributed to the inner filter effect (IFE). This work provided an effective and reliable method for the specific detection of tetracycline and was successfully applied in milk and egg samples with satisfactory recoveries (80.67–95.22%).

四环素（TC）残留不仅危害人体健康，也不利于水产养殖业和畜牧业的可持续发展。在此，基于嵌入锌基金属有机骨架中的氮掺杂碳点并结合分子印迹聚合物（ZIF-8&N-CDs@MIP），开发了一种具有高灵敏度和选择性的新型荧光传感器。通过SEM、TEM、FTIR、XRD、BET、TGA等对ZIF-8&N-CDs@MIP的理化性质进行了表征。在最佳条件下，新型传感器的检测限(LOD)为0.045 μg mL ⁻¹ TC 浓度范围为 0.1–4.0 μg mL ⁻¹. 此外，与非印迹聚合物相比，制备的印迹聚合物对四环素具有更好的吸附选择性，ZIF-8&N-CDs@MIP 的猝灭机制被证明归因于内过滤效应 (IFE)。该工作为四环素的特异性检测提供了一种有效可靠的方法，并成功应用于牛奶和鸡蛋样品，回收率令人满意 (80.67–95.22%)。