The proportionality principle has been broadly used for over 10 years in regulatory assessments of pesticide residues. It allows extrapolation of supervised field trial data conducted at lower or higher application rates compared to the use pattern under evaluation by adjustment of measured concentrations, assuming direct proportionality between the rates applied and the resulting residues. This work revisits the principle idea by using supervised residue trials sets conducted under identical conditions but with deviating application rates. Four different statistical methods were used to investigate the relationship between application rates and residue concentrations and to draw conclusions on the statistical significance of the direct proportionality assumed.

中文翻译：

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重新审视比例原则——施用率与食品中农药残留浓度之间的关系

比例原则在农药残留的监管评估中被广泛使用了 10 多年。它允许通过调整测量浓度来推断在较低或较高施用率下进行的监督田间试验数据，与评估中的使用模式相比，假设施用率与产生的残留物之间成正比。这项工作通过使用在相同条件下进行的监督残留试验集重新审视了原则思想，但施用率有所不同。四种不同的统计方法被用来研究施用率和残留浓度之间的关系，并得出关于假设的正比例关系的统计显着性的结论。