Accelerated lung function decline is relatively common from the late 20s and indicates chronic lung disease in many communities, including those living with HIV.1 2 The factors influencing and mechanisms of lung function decline in people living with HIV (PLWH) or without HIV are complex and multifactorial.2 This includes changes in the lungs and respiratory system, decreased muscle mass, and decreased lung elasticity. As we age, the lungs lose their ability to expand and contract as quickly, which can lead to a decrease in lung capacity and difficulty breathing.3 Other factors, such as smoking, exposure to pollution and chronic health conditions, can also accelerate lung function decline.4 5 Previous studies demonstrated that PLWH who are receiving adequate treatment may also have a higher prevalence of chronic respiratory disease, includingchronic obstructive pulmonary disease (COPD), emphysema and lung function decline compared with those without HIV; the decline could be even faster.2 6 This is likely due to the chronic inflammation and damage to the immune system caused by HIV, which can lead to an increased risk for lung infections and other lung-related complications.6 However, with the advancement of antiretroviral therapy (ART), PLWH can now expect a much longer life expectancy and a better quality of life. When taken correctly, ART can …

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尽管接受了充分的治疗，HIV 感染者的肺功能是否会加速下降？

肺功能加速下降从 20 多岁开始相对普遍，这表明许多社区存在慢性肺部疾病，包括 HIV 感染者。1 2 HIV 感染者 (PLWH) 或非 HIV 感染者肺功能下降的影响因素和机制很复杂和多因素。2 这包括肺部和呼吸系统的变化、肌肉质量下降以及肺部弹性下降。随着年龄的增长，肺部失去了快速扩张和收缩的能力，这会导致肺活量下降和呼吸困难。3 吸烟、接触污染和慢性健康状况等其他因素也会加速肺功能4 5 之前的研究表明，接受充分治疗的艾滋病病毒感染者和艾滋病病毒感染者也可能有更高的慢性呼吸道疾病患病率，包括慢性阻塞性肺疾病（COPD）、肺气肿和肺功能与未感染艾滋病病毒者相比下降；下降速度可能更快。2 6 这可能是由于 HIV 引起的慢性炎症和对免疫系统的损害，这可能导致肺部感染和其他肺部相关并发症的风险增加。 6 然而，随着技术进步通过抗逆转录病毒疗法 (ART)，艾滋病病毒感染者和艾滋病病毒感染者现在可以期待更长的预期寿命和更好的生活质量。如果服用得当，ART 可以…… 6 然而，随着抗逆转录病毒疗法 (ART) 的进步，艾滋病病毒感染者和艾滋病病毒感染者现在可以期待更长的预期寿命和更好的生活质量。如果服用得当，ART 可以…… 6 然而，随着抗逆转录病毒疗法 (ART) 的进步，艾滋病病毒感染者和艾滋病病毒感染者现在可以期待更长的预期寿命和更好的生活质量。如果服用得当，ART 可以……