Repeated doses of mRNA vaccines for COVID-19 result in increased proportions of anti-Spike antibodies of the IgG4 subclass, that are known to neutralize well and to form mixed immune complexes with IgG1 but in a pure form might be less effective than IgG1 or IgG3 antibodies in facilitating opsonization by phagocytes, complement fixation, and NK cell-dependent elimination of infected cells (see related Research Article by Irrgang et al . ).

中文翻译：

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它是坏的，它是好的，还是 IgG4 只是被误解了？

重复接种 COVID-19 mRNA 疫苗会导致 IgG4 亚类的抗刺突抗体比例增加，已知这些抗体可以很好地中和并与 IgG1 形成混合免疫复合物，但纯形式可能不如 IgG1 或 IgG3 有效抗体促进吞噬细胞的调理作用、补体固定和 NK 细胞依赖性消除感染细胞（参见相关研究文章灌肠等人.).