Eribulin is a structurally simplified and completely synthetic analogue of macrocyclic ketone halichondrin B. In 2010, eribulin was approved by FDA for the treatment of metastatic breast cancer (MBC). Although several research groups have reported the synthetic efforts toward eribulin, it is still a challenge to prepare eribulin in a large scale due to its complex molecular architecture. Herein, we report a novel and efficient route to the C14–C23 fragment of eribulin from cheap l-arabinose.

中文翻译：

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艾日布林 C14–C23 片段的克级合成

艾日布林是大环酮软海绵素 B 的结构简化且完全合成的类似物。2010 年，艾日布林被 FDA 批准用于治疗转移性乳腺癌 (MBC)。尽管几个研究小组已经报道了艾日布林的合成努力，但由于其复杂的分子结构，大规模制备艾日布林仍然是一个挑战。在此，我们报告了一种从廉价的l-阿拉伯糖到艾日布林 C14-C23 片段的新型高效途径。