老年和年轻患者冠状动脉旁路移植术后住院结局的比较：一项多中心回顾性研究,Journal of Cardiothoracic Surgery

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老年和年轻患者冠状动脉旁路移植术后住院结局的比较：一项多中心回顾性研究
Journal of Cardiothoracic Surgery ( IF 1.6 ) Pub Date : 2023-02-01 , DOI: 10.1186/s13019-023-02163-y
Ren-Jian-Zhi Zhang ₁ , Xin-Yi Yu ₁ , Jing Wang ₂ , Jian Lv ₃ , Ming-Huan Yu ₁ , Li Wang ₂ , Zhi-Gang Liu ₁

Affiliation

我们旨在通过分析年龄对体外循环或非体外循环 CABG 后不良事件的影响，确定年轻（≤ 65 岁）和老年（> 65 岁）患者冠状动脉旁路移植术 (CABG) 后的院内结局。大于 65 岁的患者被定义为老年患者，其他患者被定义为年轻患者。定性数据通过卡方检验或 Fisher 精确检验进行比较。通过双样本独立 t 检验或 Mann-Whitney U 检验比较定量数据。多因素二元逻辑回归用于控制混杂因素，并研究年龄对死亡等二分类结果变量的影响。在体外循环 CABG 人群中，术后院内死亡率，老年患者术后症状性脑梗死（POSCI）和术后房颤（POAF）的发生率高于年轻患者（P值<0.05），年龄>65岁与术后院内死亡率相关（OR=2.370） , P 值 = 0.031), POSCI (OR = 5.033, P 值 = 0.013), 和 POAF (OR = 1.499, P 值 < 0.001)。在非体外循环 CABG 人群中，老年患者 POAF 的发生率高于年轻患者（P 值 < 0.05），年龄 > 65 岁与 POAF 相关（OR = 1.392，P 值 = 0.011）。CABG 后的住院结局受年龄的强烈影响。在非体外循环 CABG 中，老年患者术后死亡、POSCI 和 POAF 的风险更高，而在非体外循环 CABG 中，老年患者的 POAF 风险更高。

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Comparison of in-hospital outcomes after coronary artery bypass graft surgery in elders and younger patients: a multicenter retrospective study

We aimed to identify in-hospital outcomes in young (≤ 65 years) and old (> 65 years) patients after coronary artery bypass grafting (CABG) by analyzing the effect of age on adverse events after on-pump or off-pump CABG. Patients older than 65 years were defined as older patients and others were defined as younger patients. The qualitative data were compared by chi-square or Fisher's exact tests. The quantitative data were compared by the two-sample independent t-test or Mann–Whitney U test. Multifactor binary logistic regression was used to control for confounders and to investigate the effect of age on dichotomous outcome variables such as death. In the on-pump CABG population, the postoperative in-hospital mortality, the incidence of postoperative symptomatic cerebral infarction (POSCI) and postoperative atrial fibrillation (POAF) was higher in older patients than in younger patients (P value < 0.05), and age > 65 years was associated with postoperative in-hospital mortality (OR = 2.370, P value = 0.031), POSCI (OR = 5.033, P value = 0.013), and POAF (OR = 1.499, P value < 0.001). In the off-pump CABG population, the incidence of POAF was higher in older patients than in younger patients (P value < 0.05), and age > 65 years was associated with POAF (OR = 1.392, P value = 0.011). In-hospital outcomes after CABG are strongly influenced by age. In on-pump CABG, the risk of postoperative death, POSCI, and POAF was higher in older patients, and in off-pump CABG, the risk of POAF was higher in older patients.

更新日期：2023-02-02

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