A scalable asymmetric total synthesis of (−)-emetine, a natural product alkaloid from ipecac species and one of the main active ingredients in ipecac syrup used in emetics, has been accomplished. The synthetic route featured a total of 13 steps of highly efficient chemical reactions, including catalytic asymmetric allylation and an industrial deoxygenation of an aliphatic compound, which obviated the need for any chromatographic purification. (−)-Emetine·2HCl was obtained in 12% overall yield and over 93.2% HPLC purity. The synthesis was easily scaled up to 237.1 g and should be amenable to the production of larger quantities for ongoing drug development, while the compound is currently provided as natural ipecac syrup for a clinical use.

中文翻译：

---

(−)-Emetine 的高效且可扩展的不对称全合成，具有医药级品质；第一次多字母表合成

(−)-emetine 的可扩展不对称全合成已经完成，emetine 是一种来自吐根物种的天然产物生物碱，也是催吐剂中使用的吐根糖浆中的主要活性成分之一。该合成路线共有 13 个高效化学反应步骤，包括催化不对称烯丙基化和脂肪族化合物的工业脱氧，无需任何色谱纯化。(−)-Emetine·2HCl 以 12% 的总收率和超过 93.2% 的 HPLC 纯度获得。该合成很容易放大到 237.1 克，应该可以为正在进行的药物开发生产更大数量的化合物，而该化合物目前以天然吐根糖浆的形式提供用于临床。