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Highly Efficient Asymmetric Hydrogenation Catalyzed by Iridium Complexes with Tridentate Chiral Spiro Aminophosphine Ligands
Accounts of Chemical Research ( IF 18.3 ) Pub Date : 2023-01-23 , DOI: 10.1021/acs.accounts.2c00764
Fan Yang 1 , Jian-Hua Xie 1 , Qi-Lin Zhou 1
Affiliation  

Catalytic asymmetric hydrogenation is one of the most reliable, powerful, and environmentally benign methods for the synthesis of chiral molecules with high atom economy and has been successfully applied in the industrial production of pharmaceuticals, agrochemicals, and fragrances. The key to achieving highly efficient and highly enantioselective hydrogenation reactions is the design and synthesis of chiral catalysts.

中文翻译:

具有三齿手性螺氨基膦配体的铱配合物催化的高效不对称氢化反应

催化不对称氢化是合成具有高原子经济性的手性分子的最可靠、最强大、最环保的方法之一,已成功应用于医药、农用化学品和香料的工业生产。实现高效和高对映选择性加氢反应的关键是手性催化剂的设计和合成。
更新日期:2023-01-23
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