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Hyaluronan in Adipose Tissue, Metabolic Inflammation, and Diabetes: Innocent Bystander or Guilty Party?
Diabetes ( IF 7.7 ) Pub Date : 2023-01-20 , DOI: 10.2337/db22-0676
Krzysztof Drygalski 1, 2 , Simon Lecoutre 1 , Karine Clément 1, 3 , Isabelle Dugail 1
Affiliation  

Hyaluronic acid, or hyaluronan (HA), is a nonsulfated glucosaminoglycan that has long been recognized for its hydrophilic properties and is widely used as a dermal filler. Despite much attention given to the study of other extracellular matrix (ECM) components, in the field of ECM properties and their contribution to tissue fibroinflammation, little is known of HA’s potential role in the extracellular milieu. However, recent studies suggest that it is involved in inflammatory response, diet-induced insulin resistance, adipogenesis, and autoimmunity in type 1 diabetes. Based on its unique physical property as a regulator of osmotic pressure, we emphasize underestimated implications in adipose tissue function, adipogenesis, and obesity-related dysfunction.

中文翻译:

脂肪组织中的透明质酸、代谢炎症和糖尿病:无辜的旁观者还是有罪的一方?

透明质酸或乙酰透明质酸 (HA) 是一种非硫酸化葡糖胺聚糖,长期以来因其亲水特性而被认可,并广泛用作真皮填充剂。尽管人们对其他细胞外基质 (ECM) 成分的研究给予了很多关注,但在 ECM 特性及其对组织纤维炎症的贡献领域,人们对 HA 在细胞外环境中的潜在作用知之甚少。然而,最近的研究表明,它参与 1 型糖尿病的炎症反应、饮食诱导的胰岛素抵抗、脂肪生成和自身免疫。基于其作为渗透压调节剂的独特物理特性,我们强调其对脂肪组织功能、脂肪生成和肥胖相关功能障碍的低估影响。
更新日期:2023-01-20
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