Aortic dissection is a major aortic catastrophe with a high morbidity and mortality risk, and thoracic endovascular repair (TEVAR) has recently been established as the preferred treatment option for promoting false lumen (FL) remodeling and improving hemodynamics in the true lumen. Complete thrombosis of the FL has been thought to be a prerequisite for healing of the aorta postdissection, whereas flow and pressurization of the FL caused by partial thrombosis are thought to contribute to late dilation and rupture. Therefore, it is important to anticipate FL remodeling outcomes of different TEVAR procedures to determine which one will favor complete FL thrombosis. In this paper, a spatio-temporal mathematical model is proposed to simulate thrombosis in dissection. Blood is treated as a multi-constituent mixture consisting of a linear fluid phase and a thrombus (solid) phase. The transport and reactions of chemical and biological species are incorporated using a system of coupled convection-reaction-diffusion equations to represent two interacting sub-processes in thrombosis: coagulation cascade and platelet activity. Computational fluid dynamic simulations of two in vivo problems were performed using the libraries of OpenFOAM: thrombus growth in an injured straight blood vessel and TEVAR induced thrombosis in a patient-specific acute type B aortic dissection for which multiple follow-up scans are available. For both problems, the simulated thrombus formation was consistent with experimental or clinical observations, indicating the potential applicability of this modeling approach to predict the progression of dissection in patient-specific phantoms and its further use to help surgeons personalize treatment strategy for dissection patients in the future.

主动脉夹层是一种主要的主动脉灾难，具有很高的发病率和死亡率风险，胸腔血管内修复术 (TEVAR) 最近已被确定为促进假腔 (FL) 重塑和改善真腔血流动力学的首选治疗方案。FL 的完全血栓形成被认为是主动脉夹层后愈合的先决条件，而部分血栓形成引起的 FL 的流动和加压被认为有助于晚期扩张和破裂。因此，重要的是要预测不同 TEVAR 程序的 FL 重塑结果，以确定哪一种有利于完全 FL 血栓形成。在本文中，提出了一个时空数学模型来模拟解剖中的血栓形成。血液被视为由线性液相和血栓（固）相组成的多组分混合物。使用耦合对流-反应-扩散方程系统结合化学和生物物质的传输和反应，以表示血栓形成中两个相互作用的子过程：凝血级联和血小板活性。两个的计算流体动力学模拟体内问题是使用 OpenFOAM 的库进行的：受伤的直血管中的血栓生长和 TEVAR 在患者特异性急性 B 型主动脉夹层中诱导的血栓形成，可进行多次后续扫描。对于这两个问题，模拟的血栓形成与实验或临床观察结果一致，表明这种建模方法可能适用于预测患者特定模型中夹层的进展，并进一步用于帮助外科医生为夹层患者制定个性化治疗策略未来。