Unlike RNA-TBA (rTBA), iso-rTBA, the 2′–5′-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA,Chemical Communications

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Unlike RNA-TBA (rTBA), iso-rTBA, the 2′–5′-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA
Chemical Communications ( IF 4.9 ) Pub Date : 2023-01-13 , DOI: 10.1039/d2cc05718b
Atish A Wagh _{1,

2} , Vaijayanti A Kumar _{1,

2} , Sapna Ravindranathan _{2,

3} , Moneesha Fernandes _{1,

2}

Affiliation

An antiparallel, functional RNA G-quadruplex of the 2′–5′-linked thrombin-binding aptamer (iso-rTBA) is reported for the first time. It can inhibit clotting and is remarkably stable to nuclease-degradation, besides having high thermal stability. It is thus, a superior candidate to TBA, rTBA or isoTBA, for further development as an anticoagulant.

中文翻译：

与 RNA-TBA (rTBA) 不同，iso-rTBA，即 2'-5'-连接的 RNA-凝血酶结合适体，是 TBA 的功能等价物

首次报道了 2'-5'-连接的凝血酶结合适体 (iso-rTBA) 的反平行、功能性 RNA G-四链体。除了具有高热稳定性外，它还可以抑制凝血并且对核酸酶降解非常稳定。因此，它是比 TBA、rTBA 或 isoTBA 更好的候选药物，可进一步开发为抗凝血剂。

更新日期：2023-01-18

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