PD-1 and PD-L1 are important immune checkpoint molecules that modulate T cell activity. A study now shows that PD-1 marks leukaemia stem cells (LSCs) in T cell acute lymphoblastic leukaemia and reveals therapeutic opportunities to target LSCs via anti-PD-1 therapy.

中文翻译：

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重新审视 PD-1 以靶向白血病干细胞

PD-1和PD-L1是调节T细胞活性的重要免疫检查点分子。现在的一项研究表明，PD-1 标记 T 细胞急性淋巴细胞白血病中的白血病干细胞 (LSC)，并揭示了通过抗 PD-1 疗法靶向 LSC 的治疗机会。