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Introduction to engineering the biosynthesis of fungal natural products
Natural Product Reports ( IF 11.9 ) Pub Date : 2023-01-09 , DOI: 10.1039/d2np90047e
Russell J Cox 1 , Tobias A M Gulder 2
Affiliation  

Filamentous fungi are highly diverse eukaryotes that inhabit all known ecosystems on earth. Estimates suggest that more than 2 × 106 species are likely to exist, and analyses of typical fungal genomes suggest they harbour around 50 biosynthetic gene clusters on average. The biosynthetic potential of these organisms is thus vast. Fungi produce all the main classes of secondary metabolites, and numerous hybrid compounds. Many are highly useful in medicine such as the ‘classic’ special metabolites penicillins, cephalosporins, statins and mycophenolic acid, and new antimicrobial agents such as the pleuromutilins and enfumafungins that overcome specific patterns of resistance. Fungi differentiated from bacteria more than a billion years ago, so there has been plenty of time for uniquely fungal biosynthetic systems to evolve.

中文翻译:

真菌天然产物生物合成工程导论

丝状真菌是高度多样化的真核生物,栖息在地球上所有已知的生态系统中。估计表明超过 2 × 10 6物种很可能存在,对典型真菌基因组的分析表明它们平均拥有大约 50 个生物合成基因簇。因此,这些生物体的生物合成潜力是巨大的。真菌产生所有主要类别的次级代谢产物和许多杂化化合物。许多在医学上非常有用,例如“经典”特殊代谢物青霉素、头孢菌素、他汀类药物和麦考酚酸,以及新的抗微生物剂,例如克服特定耐药性的截短侧耳素和恩夫马芬菌素。真菌在十亿多年前从细菌中分化出来,因此独特的真菌生物合成系统有足够的时间进化。
更新日期:2023-01-09
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