Hydrophilic polymers have been recognized for enhancing the physico-chemical and biological properties of synthetic polyesters in the field of cancer treatment and tissue engineering. In this article, the anticancer drug, 5-fluorouracil loaded membranes were prepared with polycaprolactone blended with chitosan, hydroxypropyl methyl cellulose and polyethylene glycol to study the drug release ability for breast cancer treatment alongside microbial infections. Solution casting method was employed to fabricate blend membranes with a combination of synthetic, natural and hydrophilic polymers and the resulted membranes were characterized by spectral, crystallographic, surface morphology, contact angle measurements and mechanical testing. Through spectral and crystallographic study, the crosslinking and chemical interactions between the drug and polymers were confirmed. Swelling capacity, drug loading efficiency and the drug release profile were studied and an optimal release of drug from the membranes was observed. The membranes showed cell viability of 60%–85% against fibroblast cell line and cytotoxicity of 60%–76% against breast cancer cells. Furthermore, microbial growth inhibition assay results revealed that the membranes possess good inhibiting property for the selected bacterial and fungal strains. The in vitro degradation studies reveals that the degradation rate of the blend membranes was found higher compared to the bare membrane. Hence, the obtained results clearly reveals that the fabricated membranes would be a promising biomaterial implant in the treatment of breast cancer cells and post-surgical microbial infections.

中文翻译：

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浇铸亲水性聚合物共混聚己内酯膜用于药物递送以根除癌细胞和病原微生物

在癌症治疗和组织工程领域，亲水性聚合物已被认为可以增强合成聚酯的物理化学和生物学特性。本文采用聚己内酯与壳聚糖、羟丙基甲基纤维素和聚乙二醇共混制备了抗癌药物5-氟尿嘧啶负载膜，以研究药物在乳腺癌和微生物感染治疗中的释放能力。采用溶液流延法制备合成、天然和亲水聚合物组合的共混膜，并通过光谱、结晶学、表面形态、接触角测量和机械测试对所得膜进行表征。通过光谱和晶体学研究，确认了药物和聚合物之间的交联和化学相互作用。研究了溶胀能力、载药效率和药物释放曲线，并观察到药物从膜中的最佳释放。这些膜对成纤维细胞系的细胞活力为 60%–85%，对乳腺癌细胞的细胞毒性为 60%–76%。此外，微生物生长抑制测定结果表明，该膜对选定的细菌和真菌菌株具有良好的抑制性能。体外降解研究表明，与裸膜相比，共混膜的降解率更高。因此，