N6-Methyladenosine (m6A) is the most abundant modification in eukaryotic mRNA, and plays important biological functions via regulating RNA fate determination. Recent studies have shown that m6A modification plays a key role in hematologic malignancies, including acute myeloid leukemia. The current growth of epitranscriptomic research mainly benefits from technological progress in detecting RNA m6A modification in a transcriptome-wide manner. In this review, we first briefly summarize the latest advances in RNA m6A biology by focusing on writers, readers, and erasers of m6A modification, and describe the development of high-throughput methods for RNA m6A mapping. We further discuss the important roles of m6A modifiers in acute myeloid leukemia, and highlight the identification of potential inhibitors for AML treatment by targeting of m6A modifiers. Overall, this review provides a comprehensive summary of RNA m6A biology in acute myeloid leukemia.

中文翻译：

---

RNA m6A 修饰：在急性髓性白血病中的定位方法、作用和机制。

N6-甲基腺苷 (m6A) 是真核生物 mRNA 中最丰富的修饰，通过调节 RNA 命运决定发挥重要的生物学功能。最近的研究表明，m6A 修饰在血液系统恶性肿瘤（包括急性髓性白血病）中起着关键作用。当前表观转录组学研究的增长主要得益于以全转录组方式检测 RNA m6A 修饰的技术进步。在这篇综述中，我们首先通过关注 m6A 修饰的作者、读者和擦除者简要总结了 RNA m6A 生物学的最新进展，并描述了 RNA m6A 映射的高通量方法的发展。我们进一步讨论了 m6A 修饰剂在急性髓性白血病中的重要作用，并强调了通过靶向 m6A 修饰剂来鉴定 AML 治疗的潜在抑制剂。