Circadian rhythm disruption (CRD) is a shared characteristic of various brain disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and major depression disorder (MDD). Disruption of circadian rhythm might be a risk factor for brain disorder incidents. From 7-day accelerometry data of 72,242 participants in UK Biobank, we derived a circadian relative amplitude variable, which to some extent reflected the degree of circadian rhythm disruption. Records of brain disorder incidents were obtained from a wide range of health outcomes across self-report, primary care, hospital inpatient data, and death data. Using multivariate Cox proportional hazard ratio regression, we created two models adjusting for different covariates. Then, linear correlations between relative amplitude and several brain morphometric measures were examined in participants with brain MRI data. After a median follow-up of around 6.1 years, 72,242 participants were included in the current study (female 54.9%; mean age 62.1 years). Individuals with reduced relative amplitude had increasing risk of all-cause dementia (Hazard ratio 1.23 [95% CI 1.15 to 1.31]), PD (1.33 [1.25 to 1.41]), stroke (1.13 [1.06 to 1.22]), MDD (1.18 [1.13 to 1.23]), and anxiety disorder (1.14 [1.09 to 1.20]) in fully adjusted models. Additionally, significant correlations were found between several cortical regions and white matter tracts and relative amplitude that have been linked to dementia and psychiatric disorders. We confirm CRD to be a risk factor for various brain disorders. Interventions for regulating circadian rhythm may have clinical relevance to reducing the risk of various brain disorders.

昼夜节律紊乱（CRD）是各种脑部疾病的共同特征，例如阿尔茨海默病（AD）、帕金森病（PD）和重度抑郁症（MDD）。昼夜节律紊乱可能是脑部疾病事件的危险因素。从英国生物银行72,242名参与者的7天加速度数据中，我们得出了昼夜节律相对幅度变量，该变量在一定程度上反映了昼夜节律紊乱的程度。脑部疾病事件的记录是从自我报告、初级保健、医院住院患者数据和死亡数据等广泛的健康结果中获得的。使用多元 Cox 比例风险比回归，我们创建了两个针对不同协变量进行调整的模型。然后，利用大脑 MRI 数据检查参与者的相对振幅和几种大脑形态测量之间的线性相关性。经过中位随访 6.1 年左右，本研究纳入了 72,242 名参与者（女性 54.9%；平均年龄 62.1 岁）。相对幅度降低的个体患全因痴呆（风险比 1.23 [95% CI 1.15 至 1.31]）、PD（1.33 [1.25 至 1.41]）、中风（1.13 [1.06 至 1.22]）、MDD（1.18）的风险增加。 [1.13 至 1.23]），以及完全调整模型中的焦虑症（1.14 [1.09 至 1.20]）。此外，在几个皮质区域和白质束之间发现了显着的相关性，以及与痴呆和精神疾病相关的相对幅度。我们确认 CRD 是各种脑部疾病的危险因素。调节昼夜节律的干预措施可能对降低各种脑部疾病的风险具有临床意义。